The fatal crash involved a tractor-trailer and at least one other vehicle, closing the street between Ronks and Leacock roads in East Lampeter Township shortly after the crash just after 7:40 a.m.
They remained closed more than three hours later, according to the Pennsylvania Department of Transportation.
The victim’s identity had not been released as of Monday afternoon.
There was no word on any additional persons injuries as of Monday morning.
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